Associations of autozygosity with a broad range of human phenotypes

David W Clark; Yukinori Okada; Kristjan H S Moore; Dan Mason; Nicola Pirastu; Ilaria Gandin; Hannele Mattsson; Catriona L K Barnes; Kuang Lin; Jing Hua Zhao; Patrick Deelen; Rebecca Rohde; Claudia Schurmann; Xiuqing Guo; Franco Giulianini; Weihua Zhang; Carolina Medina-Gomez; Robert Karlsson; Yanchun Bao; Traci M Bartz; Clemens Baumbach; Ginevra Biino; Matthew J Bixley; Marco Brumat; Jin-Fang Chai; Tanguy Corre; Diana L Cousminer; Annelot M Dekker; David A Eccles; Kristel R van Eijk; Christian Fuchsberger; He Gao; Marine Germain; Scott D Gordon; Hugoline G de Haan; Sarah E Harris; Edith Hofer; Alicia Huerta-Chagoya; Catherine Igartua; Iris E Jansen; Yucheng Jia; Tim Kacprowski; Torgny Karlsson; Marcus E Kleber; Shengchao Alfred Li; Ruifang Li-Gao; Anubha Mahajan; Koichi Matsuda; Karina Meidtner; Weihua Meng; May E Montasser; Peter J van der Most; Matthias Munz; Teresa Nutile; Teemu Palviainen; Gauri Prasad; Rashmi B Prasad; Tallapragada Divya Sri Priyanka; Federica Rizzi; Erika Salvi; Bishwa R Sapkota; Daniel Shriner; Line Skotte; Melissa C Smart; Albert Vernon Smith; Ashley van der Spek; Cassandra N Spracklen; Rona J Strawbridge; Salman M Tajuddin; Stella Trompet; Constance Turman; Niek Verweij; Clara Viberti; Lihua Wang; Helen R Warren; Robyn E Wootton; Lisa R Yanek; Jie Yao; Noha A Yousri; Wei Zhao; Adebowale A Adeyemo; Saima Afaq; Carlos Alberto Aguilar-Salinas; Masato Akiyama; Matthew L Albert; Matthew A Allison; Maris Alver; Tin Aung; Fereidoun Azizi; Amy R Bentley; Heiner Boeing; Eric Boerwinkle; Judith B Borja; Gert J de Borst; Erwin P Bottinger; Linda Broer; Harry Campbell; Stephen Chanock; Miao-Li Chee; Guanjie Chen; Yii-Der I Chen; Zhengming Chen; Yen-Feng Chiu; Massimiliano Cocca; Francis S Collins; Maria Pina Concas; Janie Corley; Giovanni Cugliari; Rob M van Dam; Anna Damulina; Maryam S Daneshpour; Felix R Day; Graciela E Delgado; Klodian Dhana; Alexander S F Doney; Marcus Dörr; Ayo P Doumatey; Nduna Dzimiri; S Sunna Ebenesersdóttir; Joshua Elliott; Paul Elliott; Ralf Ewert; Janine F Felix; Krista Fischer; Barry I Freedman; Giorgia Girotto; Anuj Goel; Martin Gögele; Mark O Goodarzi; Mariaelisa Graff; Einat Granot-Hershkovitz; Francine Grodstein; Simonetta Guarrera; Daniel F Gudbjartsson; Kamran Guity; Bjarni Gunnarsson; Yu Guo; Saskia P Hagenaars; Christopher A Haiman; Avner Halevy; Tamara B Harris; Mehdi Hedayati; David A van Heel; Makoto Hirata; Imo Höfer; Chao Agnes Hsiung; Jinyan Huang; Yi-Jen Hung; M Arfan Ikram; Anuradha Jagadeesan; Pekka Jousilahti; Yoichiro Kamatani; Masahiro Kanai; Nicola D Kerrison; Thorsten Kessler; Kay-Tee Khaw; Chiea Chuen Khor; Dominique P V de Kleijn; Woon-Puay Koh; Ivana Kolcic; Peter Kraft; Bernhard K Krämer; Zoltán Kutalik; Johanna Kuusisto; Claudia Langenberg; Lenore J Launer; Deborah A Lawlor; I-Te Lee; Wen-Jane Lee; Markus M Lerch; Liming Li; Jianjun Liu; Marie Loh; Stephanie J London; Stephanie Loomis; Yingchang Lu; Jian'an Luan; Reedik Mägi; Ani W Manichaikul; Paolo Manunta; Gísli Másson; Nana Matoba; Xue W Mei; Christa Meisinger; Thomas Meitinger; Massimo Mezzavilla; Lili Milani; Iona Y Millwood; Yukihide Momozawa; Amy Moore; Pierre-Emmanuel Morange; Hortensia Moreno-Macías; Trevor A Mori; Alanna C Morrison; Taulant Muka; Yoshinori Murakami; Alison D Murray; Renée de Mutsert; Josyf C Mychaleckyj; Mike A Nalls; Matthias Nauck; Matt J Neville; Ilja M Nolte; Ken K Ong; Lorena Orozco; Sandosh Padmanabhan; Gunnar Pálsson; James S Pankow; Cristian Pattaro; Alison Pattie; Ozren Polasek; Neil Poulter; Peter P Pramstaller; Lluis Quintana-Murci; Katri Räikkönen; Sarju Ralhan; Dabeeru C Rao; Wouter van Rheenen; Stephen S Rich; Paul M Ridker; Cornelius A Rietveld; Antonietta Robino; Frank J A van Rooij; Daniela Ruggiero; Yasaman Saba; Charumathi Sabanayagam; Maria Sabater-Lleal; Cinzia Felicita Sala; Veikko Salomaa; Kevin Sandow; Helena Schmidt; Laura J Scott; William R Scott; Bahareh Sedaghati-Khayat; Bengt Sennblad; Jessica van Setten; Peter J Sever; Wayne H-H Sheu; Yuan Shi; Smeeta Shrestha; Sharvari Rahul Shukla; Jon K Sigurdsson; Timo Tonis Sikka; Jai Rup Singh; Blair H Smith; Alena Stančáková; Alice Stanton; John M Starr; Lilja Stefansdottir; Leon Straker; Patrick Sulem; Gardar Sveinbjornsson; Morris A Swertz; Adele M Taylor; Kent D Taylor; Natalie Terzikhan; Yih-Chung Tham; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Annika Tillander; Russell P Tracy; Teresa Tusié-Luna; Ioanna Tzoulaki; Simona Vaccargiu; Jagadish Vangipurapu; Jan H Veldink; Veronique Vitart; Uwe Völker; Eero Vuoksimaa; Salma M Wakil; Melanie Waldenberger; Gurpreet S Wander; Ya Xing Wang; Nicholas J Wareham; Sarah Wild; Chittaranjan S Yajnik; Jian-Min Yuan; Lingyao Zeng; Liang Zhang; Jie Zhou; Najaf Amin; Folkert W Asselbergs; Stephan J L Bakker; Diane M Becker; Benjamin Lehne; David A Bennett; Leonard H van den Berg; Sonja I Berndt; Dwaipayan Bharadwaj; Lawrence F Bielak; Murielle Bochud; Mike Boehnke; Claude Bouchard; Jonathan P Bradfield; Jennifer A Brody; Archie Campbell; Shai Carmi; Mark J Caulfield; David Cesarini; John C Chambers; Giriraj Ratan Chandak; Ching-Yu Cheng; Marina Ciullo; Marilyn Cornelis; Daniele Cusi; George Davey Smith; Ian J Deary; Rajkumar Dorajoo; Cornelia M van Duijn; David Ellinghaus; Jeanette Erdmann; Johan G Eriksson; Evangelos Evangelou; Michele K Evans; Jessica D Faul; Bjarke Feenstra; Mary Feitosa; Sylvain Foisy; Andre Franke; Yechiel Friedlander; Paolo Gasparini; Christian Gieger; Clicerio Gonzalez; Philippe Goyette; Struan F A Grant; Lyn R Griffiths; Leif Groop; Vilmundur Gudnason; Ulf Gyllensten; Hakon Hakonarson; Anders Hamsten; Pim van der Harst; Chew-Kiat Heng; Andrew A Hicks; Hagit Hochner; Heikki Huikuri; Steven C Hunt; Vincent W V Jaddoe; Philip L De Jager; Magnus Johannesson; Åsa Johansson; Jost B Jonas; J Wouter Jukema; Juhani Junttila; Jaakko Kaprio; Sharon L R Kardia; Fredrik Karpe; Meena Kumari; Markku Laakso; Sander W van der Laan; Jari Lahti; Matthias Laudes; Rodney A Lea; Wolfgang Lieb; Thomas Lumley; Nicholas G Martin; Winfried März; Giuseppe Matullo; Mark I McCarthy; Sarah E Medland; Tony R Merriman; Andres Metspalu; Brian F Meyer; Karen L Mohlke; Grant W Montgomery; Dennis Mook-Kanamori; Patricia B Munroe; Kari E North; Dale R Nyholt; Jeffery R O'connell; Carole Ober; Albertine J Oldehinkel; Walter Palmas; Colin Palmer; Gerard G Pasterkamp; Etienne Patin; Craig E Pennell; Louis Perusse; Patricia A Peyser; Mario Pirastu; Tinca J C Polderman; David J Porteous; Danielle Posthuma; Bruce M Psaty; John D Rioux; Fernando Rivadeneira; Charles Rotimi; Jerome I Rotter; Igor Rudan; Hester M Den Ruijter; Dharambir K Sanghera; Naveed Sattar; Reinhold Schmidt; Matthias B Schulze; Heribert Schunkert; Robert A Scott; Alan R Shuldiner; Xueling Sim; Neil Small; Jennifer A Smith; Nona Sotoodehnia; E-Shyong Tai; Alexander Teumer; Nicholas J Timpson; Daniela Toniolo; David-Alexandre Tregouet; Tiinamaija Tuomi; Peter Vollenweider; Carol A Wang; David R Weir; John B Whitfield; Cisca Wijmenga; Tien-Yin Wong; John Wright; Jingyun Yang; Lei Yu; Babette S Zemel; Alan B Zonderman; Markus Perola; Patrik K E Magnusson; André G Uitterlinden; Jaspal S Kooner; Daniel I Chasman; Ruth J F Loos; Nora Franceschini; Lude Franke; Chris S Haley; Caroline Hayward; Robin G Walters; John R B Perry; Tōnu Esko; Agnar Helgason; Kari Stefansson; Peter K Joshi; Michiaki Kubo; James F Wilson

doi:10.1038/s41467-019-12283-6

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Associations of autozygosity with a broad range of human phenotypes

Journal article

Open access

Peer reviewed

Associations of autozygosity with a broad range of human phenotypes

David W Clark, Yukinori Okada, Kristjan H S Moore, Dan Mason, Nicola Pirastu, Ilaria Gandin, Hannele Mattsson, Catriona L K Barnes, Kuang Lin, Jing Hua Zhao, …

Nature Communications, Vol.10(1), 4957

2019-12-01

DOI: https://doi.org/10.1038/s41467-019-12283-6

PMCID: PMC6823371

PMID: 31673082

Abstract

Alleles

Body Size - genetics

Cognition

Consanguinity

Fertility - genetics

Haplotypes

Health Status

Homozygote

Humans

Inbreeding Depression - genetics

Risk-Taking

In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (F) for >1.4 million individuals, we show that F is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: F equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44-66%] in the odds of having children. Finally, the effects of F are confirmed within full-sibling pairs, where the variation in F is independent of all environmental confounding.

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Title: Associations of autozygosity with a broad range of human phenotypes
Creators: David W Clark - University of Edinburgh
Yukinori Okada - Osaka University
Kristjan H S Moore - Amgen
Dan Mason - Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Trust, Bradford, BD96RJ, UK
Nicola Pirastu - University of Edinburgh
Ilaria Gandin - University of Trieste
Hannele Mattsson - University of Helsinki
Catriona L K Barnes - University of Edinburgh
Kuang Lin - University of Oxford
Jing Hua Zhao - University of Cambridge
Patrick Deelen - University of Groningen
Rebecca Rohde - University of North Carolina at Chapel Hill
Claudia Schurmann - Mount Sinai Hospital
Xiuqing Guo - UCLA Medical Center
Franco Giulianini - Brigham and Women's Hospital
Weihua Zhang - Imperial College London
Carolina Medina-Gomez - Erasmus MC
Robert Karlsson - Karolinska Institutet
Yanchun Bao - University of Essex
Traci M Bartz - University of Washington
Clemens Baumbach - Helmholtz Zentrum München
Ginevra Biino - National Academies of Sciences, Engineering, and Medicine
Matthew J Bixley - University of Otago
Marco Brumat - University of Trieste
Jin-Fang Chai - National University of Singapore
Tanguy Corre - SIB Swiss Institute of Bioinformatics
Diana L Cousminer - Children's Hospital of Philadelphia
Annelot M Dekker - University Medical Center Utrecht
David A Eccles - Queensland University of Technology
Kristel R van Eijk - University Medical Center Utrecht
Christian Fuchsberger - University of Lübeck
He Gao - Imperial College London
Marine Germain - Université Paris Cité
Scott D Gordon - QIMR Berghofer Medical Research Institute
Hugoline G de Haan - Leiden University Medical Center
Sarah E Harris - University of Edinburgh
Edith Hofer - Medical University of Graz
Alicia Huerta-Chagoya - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Catherine Igartua - University of Chicago
Iris E Jansen - Vrije Universiteit Amsterdam
Yucheng Jia - UCLA Medical Center
Tim Kacprowski - Technical University of Munich
Torgny Karlsson - Science for Life Laboratory
Marcus E Kleber - Heidelberg University
Shengchao Alfred Li - Leidos
Ruifang Li-Gao - Leiden University Medical Center
Anubha Mahajan - Wellcome Centre for Human Genetics
Koichi Matsuda - The University of Tokyo
Karina Meidtner - German Center for Diabetes Research
Weihua Meng - University of Dundee
May E Montasser - University of Maryland, Baltimore
Peter J van der Most - University Medical Center Groningen
Matthias Munz - Humboldt-Universität zu Berlin
Teresa Nutile - Institute of Genetics and Biophysics
Teemu Palviainen - University of Helsinki
Gauri Prasad - Institute of Genomics and Integrative Biology
Rashmi B Prasad - Lund University
Tallapragada Divya Sri Priyanka - Centre for Cellular and Molecular Biology
Federica Rizzi - University of Milan
Erika Salvi - University of Milan
Bishwa R Sapkota - University of Oklahoma Health Sciences Center
Daniel Shriner - National Institutes of Health
Line Skotte - Statens Serum Institut
Melissa C Smart - University of Essex
Albert Vernon Smith - RMIT University
Ashley van der Spek - Erasmus MC
Cassandra N Spracklen - University of North Carolina at Chapel Hill
Rona J Strawbridge - University of Glasgow
Salman M Tajuddin - National Institutes of Health
Stella Trompet - Leiden University Medical Center
Constance Turman - Harvard University
Niek Verweij - University Medical Center Groningen
Clara Viberti - University of Turin
Lihua Wang - Washington University in St. Louis
Helen R Warren - Queen Mary University of London
Robyn E Wootton - University of Bristol
Lisa R Yanek - Johns Hopkins Medicine
Jie Yao - UCLA Medical Center
Noha A Yousri - Alexandria University
Wei Zhao - University of Michigan–Ann Arbor
Adebowale A Adeyemo - National Institutes of Health
Saima Afaq - Imperial College London
Carlos Alberto Aguilar-Salinas - Tecnológico de Monterrey
Masato Akiyama - Kyushu University
Matthew L Albert - Department of Cancer Immunology, Genentech Inc, San Francisco, California, 94080, USA
Matthew A Allison - University of California, San Diego
Maris Alver - University of Tartu
Tin Aung - National University of Singapore
Fereidoun Azizi - Shahid Beheshti University of Medical Sciences
Amy R Bentley - National Institutes of Health
Heiner Boeing - University of Potsdam
Eric Boerwinkle - The University of Texas Health Science Center at Houston
Judith B Borja - University of San Carlos
Gert J de Borst - Utrecht University
Erwin P Bottinger - Hasso Plattner Institute
Linda Broer - Erasmus MC
Harry Campbell - University of Edinburgh
Stephen Chanock - National Institutes of Health
Miao-Li Chee - National University of Singapore
Guanjie Chen - National Institutes of Health
Yii-Der I Chen - UCLA Medical Center
Zhengming Chen - University of Oxford
Yen-Feng Chiu - National Health Research Institutes
Massimiliano Cocca - University of Trieste
Francis S Collins - National Institutes of Health
Maria Pina Concas - University of Trieste
Janie Corley - University of Edinburgh
Giovanni Cugliari - University of Turin
Rob M van Dam - Harvard University
Anna Damulina - Medical University of Graz
Maryam S Daneshpour - Shahid Beheshti University of Medical Sciences
Felix R Day - University of Cambridge
Graciela E Delgado - Heidelberg University
Klodian Dhana - Harvard University
Alexander S F Doney - University of Dundee
Marcus Dörr - Universitätsmedizin Greifswald
Ayo P Doumatey - National Institutes of Health
Nduna Dzimiri - Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, KSA, 12713, Saudi Arabia
S Sunna Ebenesersdóttir - University of Iceland
Joshua Elliott - Imperial College London
Paul Elliott - Health Data Research UK
Ralf Ewert - Universitätsmedizin Greifswald
Janine F Felix - Erasmus MC
Krista Fischer - University of Tartu
Barry I Freedman - Wake Forest University
Giorgia Girotto - University of Trieste
Anuj Goel - Wellcome Centre for Human Genetics
Martin Gögele - University of Lübeck
Mark O Goodarzi - Cedars-Sinai Medical Center
Mariaelisa Graff - University of North Carolina at Chapel Hill
Einat Granot-Hershkovitz - Hadassah Medical Center
Francine Grodstein - Harvard University
Simonetta Guarrera - University of Turin
Daniel F Gudbjartsson - University of Iceland
Kamran Guity - Shahid Beheshti University of Medical Sciences
Bjarni Gunnarsson - Amgen
Yu Guo - Chinese Academy of Medical Sciences & Peking Union Medical College
Saskia P Hagenaars - University of Edinburgh
Christopher A Haiman - University of Southern California
Avner Halevy - Hadassah Medical Center
Tamara B Harris - National Institutes of Health
Mehdi Hedayati - Shahid Beheshti University of Medical Sciences
David A van Heel - Queen Mary University of London
Makoto Hirata - The University of Tokyo
Imo Höfer - Utrecht University
Chao Agnes Hsiung - National Health Research Institutes
Jinyan Huang - Shanghai Jiao Tong University
Yi-Jen Hung - National Defense Medical Center
M Arfan Ikram - Erasmus MC
Anuradha Jagadeesan - University of Iceland
Pekka Jousilahti - National Institutes of Health
Yoichiro Kamatani - Kyoto University
Masahiro Kanai - Osaka University
Nicola D Kerrison - University of Cambridge
Thorsten Kessler - Technical University of Munich
Kay-Tee Khaw - University of Cambridge
Chiea Chuen Khor - Agency for Science, Technology and Research
Dominique P V de Kleijn - Utrecht University
Woon-Puay Koh - National University of Singapore
Ivana Kolcic - University of Split
Peter Kraft - Harvard University
Bernhard K Krämer - Heidelberg University
Zoltán Kutalik - SIB Swiss Institute of Bioinformatics
Johanna Kuusisto - University of Eastern Finland
Claudia Langenberg - University of Cambridge
Lenore J Launer - National Institutes of Health
Deborah A Lawlor - Population Health Science, Bristol Medical School, Bristol, BS8 2BY, UK
I-Te Lee - Chung Shan Medical University
Wen-Jane Lee - Taichung Veterans General Hospital
Markus M Lerch - Universitätsmedizin Greifswald
Liming Li - Peking University
Jianjun Liu - Agency for Science, Technology and Research
Marie Loh - Imperial College London
Stephanie J London - National Institutes of Health
Stephanie Loomis - Johns Hopkins University
Yingchang Lu - Mount Sinai Hospital
Jian'an Luan - University of Cambridge
Reedik Mägi - University of Tartu
Ani W Manichaikul - University of Virginia
Paolo Manunta - Vita-Salute San Raffaele University
Gísli Másson - Amgen
Nana Matoba - RIKEN Center for Integrative Medical Sciences
Xue W Mei - University of Oxford
Christa Meisinger - Helmholtz Zentrum München
Thomas Meitinger - Technical University of Munich
Massimo Mezzavilla - Medical Genetics, Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy
Lili Milani - University of Tartu
Iona Y Millwood - University of Oxford
Yukihide Momozawa - RIKEN Center for Integrative Medical Sciences
Amy Moore - National Institutes of Health
Pierre-Emmanuel Morange - Aix-Marseille Université
Hortensia Moreno-Macías - Universidad Autónoma Metropolitana
Trevor A Mori - University of Western Australia
Alanna C Morrison - The University of Texas Health Science Center at Houston
Taulant Muka - University of Bern
Yoshinori Murakami - The University of Tokyo
Alison D Murray - University of Aberdeen
Renée de Mutsert - Leiden University Medical Center
Josyf C Mychaleckyj - University of Virginia
Mike A Nalls - Data Tecnica International
Matthias Nauck - Universitätsmedizin Greifswald
Matt J Neville - University of Oxford
Ilja M Nolte - University Medical Center Groningen
Ken K Ong - University of Cambridge
Lorena Orozco - Medicina
Sandosh Padmanabhan - University of Glasgow
Gunnar Pálsson - Amgen
James S Pankow - University of Minnesota
Cristian Pattaro - University of Lübeck
Alison Pattie - University of Edinburgh
Ozren Polasek - University of Split
Neil Poulter - Imperial College London
Peter P Pramstaller - University of Lübeck
Lluis Quintana-Murci - Institut Pasteur
Katri Räikkönen - University of Helsinki
Sarju Ralhan - Hero Heart Institute and Dyanand Medical College and Hospital, Ludhiana, Punjab, India
Dabeeru C Rao - Washington University in St. Louis
Wouter van Rheenen - University Medical Center Utrecht
Stephen S Rich - University of Virginia
Paul M Ridker - Harvard University
Cornelius A Rietveld - Erasmus University Rotterdam
Antonietta Robino - University of Trieste
Frank J A van Rooij - Erasmus MC
Daniela Ruggiero - Istituto Neurologico Mediterraneo
Yasaman Saba - Medical University of Graz
Charumathi Sabanayagam - National University of Singapore
Maria Sabater-Lleal - Karolinska Institutet
Cinzia Felicita Sala - San Raffaele Research Institute, Milano, Italy
Veikko Salomaa - National Institutes of Health
Kevin Sandow - UCLA Medical Center
Helena Schmidt - Medical University of Graz
Laura J Scott - University of Michigan–Ann Arbor
William R Scott - Imperial College London
Bahareh Sedaghati-Khayat - Shahid Beheshti University of Medical Sciences
Bengt Sennblad - Karolinska Institutet
Jessica van Setten - Utrecht University
Peter J Sever - Imperial College London
Wayne H-H Sheu - Institute of Medical Technology, National Chung-Hsing University, Taichung, Taiwan, Taiwan
Yuan Shi - National University of Singapore
Smeeta Shrestha - Dr. Hari Singh Gour University
Sharvari Rahul Shukla - Symbiosis International University
Jon K Sigurdsson - Amgen
Timo Tonis Sikka - University of Tartu
Jai Rup Singh - Panjab University
Blair H Smith - University of Dundee
Alena Stančáková - University of Eastern Finland
Alice Stanton - Royal College of Surgeons in Ireland
John M Starr - University of Edinburgh
Lilja Stefansdottir - Amgen
Leon Straker - Curtin University
Patrick Sulem - Amgen
Gardar Sveinbjornsson - Amgen
Morris A Swertz - University of Groningen
Adele M Taylor - University of Edinburgh
Kent D Taylor - UCLA Medical Center
Natalie Terzikhan - Ghent University Hospital
Yih-Chung Tham - National University of Singapore
Gudmar Thorleifsson - Amgen
Unnur Thorsteinsdottir - RMIT University
Annika Tillander - Karolinska Institutet
Russell P Tracy - University of Vermont
Teresa Tusié-Luna - Universidad Nacional Autónoma de México
Ioanna Tzoulaki - Imperial College London
Simona Vaccargiu - National Academies of Sciences, Engineering, and Medicine
Jagadish Vangipurapu - University of Eastern Finland
Jan H Veldink - University Medical Center Utrecht
Veronique Vitart - University of Edinburgh
Uwe Völker - Universitätsmedizin Greifswald
Eero Vuoksimaa - University of Helsinki
Salma M Wakil - Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, KSA, 12713, Saudi Arabia
Melanie Waldenberger - Helmholtz Zentrum München
Gurpreet S Wander - Dayanand Medical College & Hospital
Ya Xing Wang - Capital Medical University
Nicholas J Wareham - University of Cambridge
Sarah Wild - University of Edinburgh
Chittaranjan S Yajnik - Diabetes Unit, K.E.M. Hospital Research Centre, Pune, MAH, 411011, India
Jian-Min Yuan - University of Pittsburgh
Lingyao Zeng - Technical University of Munich
Liang Zhang - National University of Singapore
Jie Zhou - National Institutes of Health
Najaf Amin - Erasmus MC
Folkert W Asselbergs - Farr Institute of Health Informatics Research and Institute of Health Informatics, University College London, London, UK
Stephan J L Bakker - University Medical Center Groningen
Diane M Becker - Johns Hopkins Medicine
Benjamin Lehne - Imperial College London
David A Bennett - Rush University Medical Center
Leonard H van den Berg - University Medical Center Utrecht
Sonja I Berndt - National Institutes of Health
Dwaipayan Bharadwaj - Jawaharlal Nehru University
Lawrence F Bielak - University of Michigan–Ann Arbor
Murielle Bochud - University of Lausanne
Mike Boehnke - University of Michigan–Ann Arbor
Claude Bouchard - Pennington Biomedical Research Center
Jonathan P Bradfield - Children's Hospital of Philadelphia
Jennifer A Brody - University of Washington
Archie Campbell - University of Edinburgh
Shai Carmi - Hadassah Medical Center
Mark J Caulfield - Queen Mary University of London
David Cesarini - New York University
John C Chambers - Imperial College Healthcare NHS Trust
Giriraj Ratan Chandak - Centre for Cellular and Molecular Biology
Ching-Yu Cheng - National University of Singapore
Marina Ciullo - Istituto Neurologico Mediterraneo
Marilyn Cornelis - Northwestern University
Daniele Cusi - University of Milan
George Davey Smith - University of Bristol
Ian J Deary - University of Edinburgh
Rajkumar Dorajoo - Agency for Science, Technology and Research
Cornelia M van Duijn - University of Oxford
David Ellinghaus - Kiel University
Jeanette Erdmann - University of Lübeck
Johan G Eriksson - University of Helsinki
Evangelos Evangelou - Imperial College London
Michele K Evans - National Institutes of Health
Jessica D Faul - University of Michigan–Ann Arbor
Bjarke Feenstra - Statens Serum Institut
Mary Feitosa - Supreme Council Of Health
Sylvain Foisy - Montreal Heart Institute
Andre Franke - Kiel University
Yechiel Friedlander - Hadassah Medical Center
Paolo Gasparini - University of Trieste
Christian Gieger - German Center for Diabetes Research
Clicerio Gonzalez - Instituto Nacional de Salud Pública
Philippe Goyette - Montreal Heart Institute
Struan F A Grant - Children's Hospital of Philadelphia
Lyn R Griffiths - Queensland University of Technology
Leif Groop - University of Helsinki
Vilmundur Gudnason - RMIT University
Ulf Gyllensten - Science for Life Laboratory
Hakon Hakonarson - Children's Hospital of Philadelphia
Anders Hamsten - Cardiovascular Medicine Unit, Department of Medicine Solna, Centre for Molecular Medicine, Stockholm, 171 76, Sweden
Pim van der Harst - University Medical Center Groningen
Chew-Kiat Heng - National University of Singapore
Andrew A Hicks - University of Lübeck
Hagit Hochner - Hadassah Medical Center
Heikki Huikuri - Oulu University Hospital
Steven C Hunt - Cornell University
Vincent W V Jaddoe - Erasmus MC
Philip L De Jager - Broad Institute
Magnus Johannesson - Stockholm School of Economics, Department of Economics
Åsa Johansson - Science for Life Laboratory
Jost B Jonas - Capital Medical University
J Wouter Jukema - Leiden University Medical Center
Juhani Junttila - Oulu University Hospital
Jaakko Kaprio - University of Helsinki
Sharon L R Kardia - University of Michigan–Ann Arbor
Fredrik Karpe - University of Oxford
Meena Kumari - University of Essex
Markku Laakso - University of Eastern Finland
Sander W van der Laan - Utrecht University
Jari Lahti - University of Helsinki
Matthias Laudes - University Hospital Schleswig-Holstein
Rodney A Lea - Queensland University of Technology
Wolfgang Lieb - Kiel University
Thomas Lumley - University of Auckland
Nicholas G Martin - QIMR Berghofer Medical Research Institute
Winfried März - Heidelberg University
Giuseppe Matullo - University of Turin
Mark I McCarthy - University of Oxford
Sarah E Medland - College Station Medical Center
Tony R Merriman - University of Otago
Andres Metspalu - University of Tartu
Brian F Meyer - Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, 11211, Saudi Arabia
Karen L Mohlke - University of North Carolina at Chapel Hill
Grant W Montgomery - University of Queensland
Dennis Mook-Kanamori - Leiden University Medical Center
Patricia B Munroe - Queen Mary University of London
Kari E North - University of North Carolina at Chapel Hill
Dale R Nyholt - Queensland University of Technology
Jeffery R O'connell - Genomic
Carole Ober - University of Chicago
Albertine J Oldehinkel - University Medical Center Groningen
Walter Palmas - Columbia University Irving Medical Center
Colin Palmer - University of Dundee
Gerard G Pasterkamp - Utrecht University
Etienne Patin - Institut Pasteur
Craig E Pennell - University of Newcastle Australia
Louis Perusse - Université Laval
Patricia A Peyser - University of Michigan–Ann Arbor
Mario Pirastu - National Academies of Sciences, Engineering, and Medicine
Tinca J C Polderman - Vrije Universiteit Amsterdam
David J Porteous - University of Edinburgh
Danielle Posthuma - Vrije Universiteit Amsterdam
Bruce M Psaty - University of Washington
John D Rioux - Université de Montréal
Fernando Rivadeneira - Erasmus MC
Charles Rotimi - National Institutes of Health
Jerome I Rotter - UCLA Medical Center
Igor Rudan - University of Edinburgh
Hester M Den Ruijter - University Medical Center Utrecht
Dharambir K Sanghera - University of Oklahoma Health Sciences Center
Naveed Sattar - University of Glasgow
Reinhold Schmidt - Medical University of Graz
Matthias B Schulze - University of Potsdam
Heribert Schunkert - Technical University of Munich
Robert A Scott - University of Cambridge
Alan R Shuldiner - University of Maryland, Baltimore
Xueling Sim - National University of Singapore
Neil Small - University of Bradford
Jennifer A Smith - University of Michigan–Ann Arbor
Nona Sotoodehnia - University of Washington
E-Shyong Tai - National University of Singapore
Alexander Teumer - Universitätsmedizin Greifswald
Nicholas J Timpson - University of Bristol
Daniela Toniolo - San Raffaele Research Institute, Milano, Italy
David-Alexandre Tregouet - Université Paris Cité
Tiinamaija Tuomi - University of Helsinki
Peter Vollenweider - University of Lausanne
Carol A Wang - University of Newcastle Australia
David R Weir - University of Michigan–Ann Arbor
John B Whitfield - QIMR Berghofer Medical Research Institute
Cisca Wijmenga - University of Groningen
Tien-Yin Wong - National University of Singapore
John Wright - Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Trust, Bradford, BD96RJ, UK
Jingyun Yang - Rush University Medical Center
Lei Yu - Rush University Medical Center
Babette S Zemel - Children's Hospital of Philadelphia
Alan B Zonderman - National Institutes of Health
Markus Perola - National Institutes of Health
Patrik K E Magnusson - Karolinska Institutet
André G Uitterlinden - Erasmus University Rotterdam
Jaspal S Kooner - Imperial College London
Daniel I Chasman - Harvard University
Ruth J F Loos - Icahn School of Medicine at Mount Sinai
Nora Franceschini - University of North Carolina at Chapel Hill
Lude Franke - University of Groningen
Chris S Haley - University of Edinburgh
Caroline Hayward - University of Edinburgh
Robin G Walters - University of Oxford
John R B Perry - University of Cambridge
Tōnu Esko - University of Tartu
Agnar Helgason - University of Iceland
Kari Stefansson - RMIT University
Peter K Joshi - University of Edinburgh
Michiaki Kubo - RIKEN Center for Integrative Medical Sciences
James F Wilson - University of Edinburgh
Publication Details: Nature Communications, Vol.10(1), 4957
Publisher: Springer Nature
Copyright: © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Academic Unit: Department of Economics
Language: English
Resource Type: Journal article

Associations of autozygosity with a broad range of human phenotypes

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