Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Magnus Johannesson; Aysu Okbay; Bart M. L. Baselmans; Jan Emmanuel De Neve; Patrick Turley; Michel M. Nivard; Mark Alan Fontana; S. Fleur W. Meddens; Richard Karlsson- Linnér; Cornelius A. Rietveld; Jaime Derringer; Jacob Gratten; James J. Lee; Jimmy Z. Liu; Ronald de Vlaming; Tarunveer Singh Ahluwalia; Jadwiga Buchwald; Alana Cavadino; Alexis C. Frazier-Wood; Nicholas A Furlotte; Victoria Garfield; Marie Henrike Geisel; Juan R Gonzalez; Saskia Haitjema; Robert Karlsson; Sander W. Van der Laan; Karl-Heinz Ladwig; Jari Lahti; Sven J van der Lee; Penelope A. Lind; Tian Liu; Lindsay K. Matteson; Evelin Mihailov; Mike B. Miller; Camelia C Minica; IM Nolte; Dennis Mook-Kanamori; Peter Johannes Van der Most; Christopher Oldmeadow; Yong Qian; Olli Raitakari; Rajesh Rawal; Anu Realo; Rico Rueedi; Börge Schmidt; Albert Vernon Smith; Evie Stergiakouli; Toshiko Tanaka; Kent Taylor; Gudmar Thorleifsson; Juho Wedenoja; Juergen Wellmann; Harm-Jan Westra; Sara M Willems; Wei Zhao; Najaf Amin; Andrew Bakshi; Sven Bergmann; Gyda Bjornsdottir; Patricia A. Boyle; Samantha Cherney; Oliver S. P. Davis; Jun Ding; Nese Direk; Peter Eibich; Rebecca T Emeny; Ghazaleh Fatemifar; Jessica D. Faul; Luigi Ferrucci; Andreas J. Forstner; Christian Gieger; Richa Gupta; Tamara B. Harris; Juliette M Harris; Elizabeth G Holliday; Jouke-Jan Hottenga; Philip L. De Jager; Marika A Kaakinen; Eero Kajantie; Ville Karhunen; Ivana Kolcic; Meena Kumari; Lenore J. Launer; Lude Franke; Ruifang Li-Gao; David C. Liewald; Marisa Koini; Anu Loukola; Pedro Marques-Vidal; Grant W Montgomery; Miriam A. Mosing; Lavinia Paternoster; Alison Pattie; Katja E Petrovic; Laura Pulkki-Råback; Lydia Quaye; Katri Räikkönen; Igor Rudan; Rodney J. Scott; Jennifer A. Smith; Angelina R. Sutin; Maciej Trzaskowski; Anna A E Vinkhuyzen; Lei Yu; Delilah Zabaneh; John R. Attia; David A. Bennett; Klaus Berger; Lars Bertram; Dorret I. Boomsma; H Snieder; Shun-Chiao Chang; Francesco Cucca; Ian J. Deary; Cornerlia M. van Duijn; Johan G Eriksson; Ute Bültmann; Eco J C de Geus; Patrick J. F. Groenen; Vilmundur Gudnason; Torben Hansen; Catharina A. Hartman; Claire M. A. Haworth; Caroline Hayward; Andrew C. Heath; David A. Hinds; Elina Hyppönen; William G. Iacono; Marjo-Riitta Järvelin; Karl-Heinz Jöckel; Jaakko Kaprio; Sharon L R Kardia; Liisa Keltikangas-Järvinen; Peter Kraft; Laura D Kubzansky; Terho Lehtimäki; Patrik K. E. Magnusson; N.G. Martin; Matt McGue; Andres Metspalu; Melinda Mills; Renée de Mutsert; Albertine J. Oldehinkel; Gerard Pasterkamp; Nancy L. Pedersen; Robert Plomin; Ozren Polasek; Christine Power; Stephen S. Rich; Frits R Rosendaal; Hester M den Ruijter; David Schlessinger; Reinhold Schmidt; Helena Schmidt; Rauli Svento; Behrooz Z Alizadeh; Thorkild I A Sørensen; Tim D Spector; John M. Starr; Kari Stefansson; Andrew Steptoe; Antonio Terracciano; Unnur Thorsteinsdottir; A. Roy Thurik; Nicholas J Timpson; Henning Tiemeier; André G. Uitterlinden; Peter Vollenweider; Gert G Wagner; David R Weir; Jian Yang; Dalton Conley; George Davey-Smith; David Laibson; Sara E. Medland; Michelle N Meyer; Joseph K. Pickrell; Robert Frederick Krueger; Jonathan P Beauchamp; Philipp D. Koellinger; Daniel J. Benjamin; Meike Bartels; David Cesarini; Simon R Cox; Gail Davies; Tõnu Esko; Albert Hofman

doi:10.1038/ng.3552

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Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

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Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Magnus Johannesson, Aysu Okbay, Bart M. L. Baselmans, Jan Emmanuel De Neve, Patrick Turley, Michel M. Nivard, Mark Alan Fontana, S. Fleur W. Meddens, Richard Karlsson- Linnér, Cornelius A. Rietveld, …

Nature Genetics, Vol.48, pp.624-+

2016

DOI: https://doi.org/10.1038/ng.3552

Abstract

Genetics & Heredity;Genetics & Heredity

Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (vertical bar(p) over cap vertical bar approximate to 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

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Title: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Creators - without role: Magnus Johannesson - Stockholm School of Economics, Department of Economics
Aysu Okbay - Erasmus School of Economics (NL)
Bart M. L. Baselmans - VU University (NL)
Jan Emmanuel De Neve - London School of Economics and Political Science (GB)
Patrick Turley - Massachusetts General Hospital (US)
Michel M. Nivard - VU University (NL)
Mark Alan Fontana - University of Southern California (US)
S. Fleur W. Meddens - Erasmus University (NL)
Richard Karlsson- Linnér - Erasmus University (NL)
Cornelius A. Rietveld - Erasmus University (NL)
Jaime Derringer - University of Illinois (US)
Jacob Gratten - University of Queensland (AU)
James J. Lee - University of Minnesota Twin Cities (US)
Jimmy Z. Liu - New York Genome Center
Ronald de Vlaming - Erasmus School of Economics (NL)
Tarunveer Singh Ahluwalia - Copenhagen University (DK)
Jadwiga Buchwald - University of Helsinki (FI)
Alana Cavadino - Queen Mary University of London
Alexis C. Frazier-Wood - Baylor College of Medicine
Nicholas A Furlotte - 23andMe
Victoria Garfield - University College London (GB)
Marie Henrike Geisel - University Hospital of Essen
Juan R Gonzalez - Institute for Global Health
Saskia Haitjema - UMC Utrecht
Robert Karlsson - Karolinska Institutet (SE)
Sander W. Van der Laan - UMC Utrecht
Karl-Heinz Ladwig - Helmholtz Zentrum München-German Research Center for Environmental Health
Jari Lahti - University of Helsinki (FI)
Sven J van der Lee - Erasmus Medical Center
Penelope A. Lind - QIMR Berghofer Medical Research Institute
Tian Liu - Max Planck Institute for Molecular Genetics
Lindsay K. Matteson - University of Minnesota Twin Cities (US)
Evelin Mihailov - Bristol University (GB)
Mike B. Miller - University of Minnesota Twin Cities (US)
Camelia C Minica - Vrije Universiteit Amsterdam (NL)
IM Nolte - University of Groningen (NL)
Dennis Mook-Kanamori - Leiden University
Peter Johannes Van der Most - University of Groningen (NL)
Christopher Oldmeadow - Hunter Medical Research Institute
Yong Qian - National Institute on Aging (US)
Olli Raitakari - University of Turku
Rajesh Rawal - Helmholtz Zentrum München-German Research Center for Environmental Health
Anu Realo - University of Tartu
Rico Rueedi - University of Lausanne
Börge Schmidt - University Hospital of Essen
Albert Vernon Smith - Icelandic Heart Association (IS)
Evie Stergiakouli - Bristol University (GB)
Toshiko Tanaka - National Institute on Aging (US)
Kent Taylor - Los Angeles Biomedical Research Institute
Gudmar Thorleifsson - deCODE Genetics
Juho Wedenoja - University of Helsinki (FI)
Juergen Wellmann - University of Münster
Harm-Jan Westra - Brigham and Women's Hospital and Harvard Medical School
Sara M Willems - Erasmus Medical Center
Wei Zhao - University of Michigan (US)
Najaf Amin - Erasmus Medical Center
Andrew Bakshi - University of Queensland (AU)
Sven Bergmann - University of Lausanne
Gyda Bjornsdottir - deCODE Genetics
Patricia A. Boyle - Rush University Medical Center
Samantha Cherney - RAND Corporation
Oliver S. P. Davis - Bristol University (GB)
Jun Ding - National Institute on Aging (US)
Nese Direk - Erasmus Medical Center
Peter Eibich - University of Oxford (GB)
Rebecca T Emeny - Helmholtz Zentrum München-German Research Center for Environmental Health
Ghazaleh Fatemifar - University College London (GB)
Jessica D. Faul - University of Michigan (US)
Luigi Ferrucci - National Institute on Aging (US)
Andreas J. Forstner - University of Bonn
Christian Gieger - Helmholtz Zentrum München-German Research Center for Environmental Health
Richa Gupta - University of Helsinki (FI)
Tamara B. Harris - National Institute on Aging (US)
Juliette M Harris - King's College London (GB)
Elizabeth G Holliday - Newcastle University
Jouke-Jan Hottenga - VU University (NL)
Philip L. De Jager - Harvard University (US)
Marika A Kaakinen - Imperial College (GB)
Eero Kajantie - National Institute for Health and Welfare
Ville Karhunen - University of Oulu (FI)
Ivana Kolcic - University of Split
Meena Kumari - University of Essex (GB)
Lenore J. Launer - National Institute on Aging (US)
Lude Franke - University of Groningen (NL)
Ruifang Li-Gao - Leiden University
David C. Liewald - University of Edinburgh
Marisa Koini - Medical University of Graz
Anu Loukola - University of Helsinki (FI)
Pedro Marques-Vidal - University of Lausanne
Grant W Montgomery - QIMR Berghofer Medical Research Institute
Miriam A. Mosing - Karolinska Institutet (SE)
Lavinia Paternoster - Bristol University (GB)
Alison Pattie - University of Edinburgh
Katja E Petrovic - Medical University of Graz
Laura Pulkki-Råback - University of Helsinki (FI)
Lydia Quaye - King's College London (GB)
Katri Räikkönen - University of Helsinki (FI)
Igor Rudan - University of Edinburgh
Rodney J. Scott - Newcastle University
Jennifer A. Smith - University of Michigan (US)
Angelina R. Sutin - National Institute on Aging (US)
Maciej Trzaskowski - University of Queensland (AU)
Anna A E Vinkhuyzen - University of Queensland (AU)
Lei Yu - Rush University Medical Center
Delilah Zabaneh - King's College London (GB)
John R. Attia - Hunter Medical Research Institute
David A. Bennett - Rush University Medical Center
Klaus Berger - University of Münster
Lars Bertram - University of Lübeck
Dorret I. Boomsma - VU University (NL)
H Snieder - University of Groningen (NL)
Shun-Chiao Chang - Brigham and Women's Hospital and Harvard Medical School
Francesco Cucca - Institute for Genetic and Biomedical Research CNR
Ian J. Deary - University of Edinburgh
Cornerlia M. van Duijn - Leiden University
Johan G Eriksson - Folkhälsan Research Centre
Ute Bültmann - University of Groningen (NL)
Eco J C de Geus - VU University (NL)
Patrick J. F. Groenen - Erasmus School of Economics (NL)
Vilmundur Gudnason - Icelandic Heart Association (IS)
Torben Hansen - Copenhagen University (DK)
Catharina A. Hartman - University of Groningen (NL)
Claire M. A. Haworth - Bristol University (GB)
Caroline Hayward - University of Edinburgh
Andrew C. Heath - Washington University (US)
David A. Hinds - 23andMe
Elina Hyppönen - Institute of Child Health (GB)
William G. Iacono - University of Minnesota Twin Cities (US)
Marjo-Riitta Järvelin - Imperial College (GB)
Karl-Heinz Jöckel - University Hospital of Essen
Jaakko Kaprio - University of Helsinki (FI)
Sharon L R Kardia - University of Michigan (US)
Liisa Keltikangas-Järvinen - University of Helsinki (FI)
Peter Kraft - Harvard University (US)
Laura D Kubzansky - Harvard T.H. Chan School of Public Health
Terho Lehtimäki - University of Tampere (FI)
Patrik K. E. Magnusson - Karolinska Institutet (SE)
N.G. Martin - Queensland Institute of Medical Research
Matt McGue - University of Minnesota Twin Cities (US)
Andres Metspalu - University of Tartu
Melinda Mills - University of Oxford (GB)
Renée de Mutsert - Leiden University
Albertine J. Oldehinkel - University of Groningen (NL)
Gerard Pasterkamp - UMC Utrecht
Nancy L. Pedersen - Karolinska Institutet (SE)
Robert Plomin - King's College London (GB)
Ozren Polasek - University of Split
Christine Power - South Australian Health and Medical Research Institute
Stephen S. Rich - University of Virginia (US)
Frits R Rosendaal - Leiden University
Hester M den Ruijter - UMC Utrecht
David Schlessinger - National Institute on Aging (US)
Reinhold Schmidt - Medical University of Graz
Helena Schmidt - Medical University of Graz
Rauli Svento - Oulu Business School
Behrooz Z Alizadeh - University of Groningen (NL)
Thorkild I A Sørensen - Copenhagen University (DK)
Tim D Spector - King's College London (GB)
John M. Starr - University of Edinburgh
Kari Stefansson - deCODE Genetics
Andrew Steptoe - University College London (GB)
Antonio Terracciano - National Institute on Aging (US)
Unnur Thorsteinsdottir - University of Iceland
A. Roy Thurik - Erasmus School of Economics (NL)
Nicholas J Timpson - Bristol University (GB)
Henning Tiemeier - Erasmus University (NL)
André G. Uitterlinden - Erasmus University (NL)
Peter Vollenweider - University of Lausanne
Gert G Wagner - Berlin University of Technology
David R Weir - University of Michigan (US)
Jian Yang - University of Queensland (AU)
Dalton Conley - New York University
George Davey-Smith - Bristol University (GB)
David Laibson - Harvard University (US)
Sara E. Medland - Queensland Institute of Medical Research
Michelle N Meyer - Clarkson University
Joseph K. Pickrell - New York Genome Center
Robert Frederick Krueger - University of Minnesota Twin Cities (US)
Jonathan P Beauchamp - Harvard University (US)
Philipp D. Koellinger - Erasmus School of Economics (NL)
Daniel J. Benjamin - Cornell University (US)
Meike Bartels - Institute for Research in Extramural Medicine (NL)
David Cesarini - Center for Experimental Social Science
Simon R Cox - University of Edinburgh
Gail Davies - University of Edinburgh
Tõnu Esko - University of Tartu
Albert Hofman - Erasmus University (NL)
Publication Details: Nature Genetics, Vol.48, pp.624-+
Publisher: Nature Research (part of Springer Nature)
Number of pages: 624-+
Identifiers: 991001480763206056
Academic Unit: Department of Economics
Language: English
Resource Type: Journal article

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

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