Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

Magnus Johannesson; Robert A. Power; Stacy Steinberg; Gyda Bjornsdottir; Cornelius A. Rietveld; Abdel Abdellaoui; Michel M. Nivard; Tessel E. Galesloot; Jouke-Jan Hottenga; Gonneke Willemsen; David Cesarini; Daniel J. Benjamin; Patrik K. E. Magnusson; Fredrik Ullén; Henning Tiemeier; Albert Hofman; Frank J A Van Rooij; Bragi Walters; Engilbert Sigurdsson; Thorgeir E. Thorgeirsson; Andres Ingason; Agnar Helgason; Augustine Kong; Lambertus A Kiemeney; Philipp D. Koellinger; Dorret I. Boomsma; Daniel Gudbjartsson; Kari Stefansson; Hreinn Stefansson

doi:10.1038/nn.4040

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Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

Journal article

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Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

Magnus Johannesson, Robert A. Power, Stacy Steinberg, Gyda Bjornsdottir, Cornelius A. Rietveld, Abdel Abdellaoui, Michel M. Nivard, Tessel E. Galesloot, Jouke-Jan Hottenga, Gonneke Willemsen, …

Nature Neuroscience, Vol.18(7), pp.953-+

2015

DOI: https://doi.org/10.1038/nn.4040

Abstract

Neurosciences;Neurosciences & Neurology

We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 x 10(-6) and 3.8 x 10(-6) for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.

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Title: Polygenic risk scores for schizophrenia and bipolar disorder predict creativity
Creators - without role: Magnus Johannesson - Stockholm School of Economics, Department of Economics
Robert A. Power - deCODE Genetics
Stacy Steinberg - deCODE Genetics
Gyda Bjornsdottir - deCODE Genetics
Cornelius A. Rietveld - Erasmus University (NL)
Abdel Abdellaoui - VU University (NL)
Michel M. Nivard - VU University (NL)
Tessel E. Galesloot - Radboud University (NL)
Jouke-Jan Hottenga - VU University (NL)
Gonneke Willemsen - VU University (NL)
David Cesarini - Center for Experimental Social Science
Daniel J. Benjamin - Cornell University (US)
Patrik K. E. Magnusson - Karolinska Institutet (SE)
Fredrik Ullén - Karolinska Institutet (SE)
Henning Tiemeier - Erasmus University (NL)
Albert Hofman - Erasmus University (NL)
Frank J A Van Rooij - Erasmus University (NL)
Bragi Walters - deCODE Genetics
Engilbert Sigurdsson - University of Iceland
Thorgeir E. Thorgeirsson - deCODE Genetics
Andres Ingason - deCODE Genetics
Agnar Helgason - deCODE Genetics
Augustine Kong - University of Iceland
Lambertus A Kiemeney - Radboud University (NL)
Philipp D. Koellinger - Erasmus School of Economics (NL)
Dorret I. Boomsma - VU University (NL)
Daniel Gudbjartsson - deCODE Genetics
Kari Stefansson - deCODE Genetics
Hreinn Stefansson - deCODE Genetics
Publication Details: Nature Neuroscience, Vol.18(7), pp.953-+
Publisher: Nature Publishing Group
Number of pages: 953-+
Identifiers: 991001480594806056
Academic Unit: Department of Economics
Language: English
Resource Type: Journal article

Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

Abstract

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